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NCTM1111 – Downstream Manufacturing
May 18, 2020 @ 8:00 am - May 22, 2020 @ 5:00 pm
Description
Hands-on training provides a thorough review of the most commonly utilized techniques involved in the downstream processes for manufacturing biologics. Lectures and laboratories cover concepts in sterile buffer preparation, initial product clarification and recovery, various modes of filtration and column chromatography. Practical training includes techniques in buffer preparation, sterile filtration, cell lysis, centrifugation, product clarification, tangential flow filtration, UNICORN chromatography software training, column packing, ion exchange and hydrophobic interaction chromatography. Participants are exposed to operating pilot-scale equipment after learning techniques and concepts at bench scale. Critical parameters to be considered during each unit operation along with available single-use options are also discussed in this course. Quality systems and analytics relating to downstream manufacturing processes are also integrated throughout the week.
Section Description
This course is a stand-alone, open enrollment course and is not a part of the NCTM Advanced Certificate in Biopharmaceutical Manufacturing.